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Critically Appraised Topic
Is rifaximin an effective treatment option for irritable bowel syndrome?
Rachel E. Smith, BSN
, Wilson Crone, MD, PhD December 22, 2011
Research suggests that rifaximin could offer symptom relief to IBS patients who have not had success with traditional medications and lifestyle modifications.
Can an ACE inhibitor reduce the risk of developing progressive renal disease?
Lauren Jewett, MMS, PA-C
, Mark E. Archambault, DHSc, PA-C September 15, 2011
Using CCBs to treat hypertension in African Americans based on the perception that they have increased efficacy may do little to prevent ESRD.
Do drospirenone-containing oral contraceptives have a higher risk of VTE?
Jennifer Hofmann Ribowsky, MS, RPA-C
August 11, 2011
Because these products are among the top-selling OCs in the United States, awareness of the evidence regarding their safety is essential.
Should etomidate be used for emergency intubation in patients with sepsis?
Michael Halasy, MS, PA-C
April 08, 2011
The ED community has preferred etomidate for intubation because of its reduced hemodynamic effects, but it is associated with a definite increase in adrenal suppression.
Does genetic screening reduce adverse effects when initiating warfarin therapy?
David S. Fox
March 24, 2011
Although data show a correlation between using a pharmacogenetic algorithm and shorter times to a stable warfarin dose and more time spent in the therapeutic range, it is unclear whether these factors cause a significant decrease in adverse clinical events.
Is prasugrel more effective than clopidogrel at preventing future cardiac events?
Catherine G. Lange, PA-C, MS
February 11, 2011
Although the risks and benefits of using prasugrel should be evaluated on a case-by-case basis, prasugrel can be considered for selected patients because of its increased rates of effectiveness over clopidogrel.
Does estrogen therapy improve the symptoms of stress urinary incontinence?
Mark E. Archambault, DHSc, PA-C
December 16, 2010
One formulation of estrogen may be helpful in postmenopausal women with stress urinary incontinence, but it isn't necessarily the best available treatment approach.
MMR vaccine and autism: Is there a link?
Melissa L. Kemp, MPAS, PA-C; M. Beth Hart, MD, FAAP June 15, 2010
A focused search identifies three studies that disprove the theory of a causal relationship between autism and vaccines.
Should patients at low-to-moderate cardiac risk receive beta-blockers before undergoing noncardiac surgery?
Jennifer S. Williams, MMS, PA-C; Kristen K. Will, MHPE, PA-C; Zachary C. Hartsell, MPAS, PA-C; Adriane I. Budavari, MD March 29, 2010
A search of the literature does not support using beta-blocker therapy in patients at lower risks for cardiac events prior to noncardiac surgery.
Is black cohosh a safe and effective substitute for hormone replacement therapy?
Elizabeth Becker; Tanya Letham; James D. Stoehr, PhD September 29, 2009
A search of the literature found that patients who wish to avoid hormone replacement therapy are not likely to find relief of their symptoms with this alternative.
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