myCME Spotlight

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Critically Appraised Topic

When does treatment of subclinical 
hypothyroidism reduce cardiovascular risk?

, Mark E. Archambault, DHSc, PA-C February 21, 2012

Patients with subclinical hypothyroidism may have a higher risk of coronary events and in some cases should be treated.
 

Is rifaximin an effective treatment option for irritable bowel syndrome?

, Wilson Crone, MD, PhD December 22, 2011

Research suggests that rifaximin could offer symptom relief to IBS patients who have not had success with traditional medications and lifestyle modifications.
 

Can an ACE inhibitor reduce the risk of 
developing progressive renal disease?

, Mark E. Archambault, DHSc, PA-C September 15, 2011

Using CCBs to treat hypertension in African Americans based on the perception that they have increased efficacy may do little to prevent ESRD.
 

Do drospirenone-containing oral 
contraceptives have a higher risk of VTE?

August 11, 2011

Because these products are among the top-selling OCs in the United States, awareness of the evidence regarding their safety is essential.
 

Should etomidate be used for emergency 
intubation in patients with sepsis?

April 08, 2011

The ED community has preferred etomidate for intubation because of its reduced hemodynamic effects, but it is associated with a definite increase in adrenal suppression.
 

Does genetic screening reduce adverse 
effects when initiating warfarin therapy?

March 24, 2011

Although data show a correlation between using a pharmacogenetic algorithm and shorter times to a stable warfarin dose and more time spent in the therapeutic range, it is unclear whether these factors cause a significant decrease in adverse clinical events.
 

Is prasugrel more effective than clopidogrel at preventing future cardiac events?

February 11, 2011

Although the risks and benefits of using prasugrel should be evaluated on a case-by-case basis, prasugrel can be considered for selected patients because of its increased rates of effectiveness over clopidogrel.
 

Does estrogen therapy improve the 
symptoms of stress urinary incontinence?

December 16, 2010

One formulation of estrogen may be helpful in postmenopausal women with stress urinary incontinence, but it isn't necessarily the best available treatment approach.
 

MMR vaccine and autism: Is there a link?

Melissa L. Kemp, MPAS, PA-C; M. Beth Hart, MD, FAAP June 15, 2010

A focused search identifies three studies that disprove the theory of a causal relationship between autism and vaccines.
 

Should patients at low-to-moderate cardiac risk receive beta-blockers before undergoing noncardiac surgery?

Jennifer S. Williams, MMS, PA-C; Kristen K. Will, MHPE, PA-C; Zachary C. Hartsell, MPAS, PA-C; Adriane I. Budavari, MD March 29, 2010

A search of the literature does not support using beta-blocker therapy in patients at lower risks for cardiac events prior to noncardiac surgery.
 
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