July 01, 2007
Herpes zoster, or shingles, is caused by the reactivation of the latent varicella-zoster virus (VZV) within the sensory ganglia. The term shingles comes from the Latin word cingulum, which means belt or girdle, and refers to the characteristic rash that commonly appears as a band or belt on the trunk of patients with active
infection. What causes the virus to emerge from latency is not completely understood, but waning cell-mediated immunity is linked directly to the reactivation. This theory is the basis of research that led to the development of this vaccine.