Pharmacology Consult

Clostridium difficile infection: 
Managing the risks

May 11, 2012

Proton pump inhibitors can increase the risk of C difficile infection, and some types of probiotics have a role in treatment and prevention.
 

DVT prophylaxis with aspirin
in orthopedic surgery patients

April 04, 2012

The 2012 ACCP guidelines on thromboprophylaxis after orthopedic surgery contain some surprises, basing recommendations on the type of surgery and sometimes countermanding earlier versions.
 

How do dihydropyridine and nondihydropyridine CCBs differ?

March 07, 2012

All calcium channel blockers have a similar mechanism of action, but they are not interchangeable and can exert very different physiologic effects.
 

Phenytoin: An old friend that 
still confuses us

February 07, 2012

Dosing of phenytoin is complicated by its unique properties: it is highly lipophilic, highly protein-bound, and undergoes capacity-limited pharmacokinetics at therapeutic levels.
 

Prescribing opioids safely in 
patients with an opiate allergy

January 09, 2012

IgE-mediated allergy to opioids is rare but life-threatening, so distinguishing between a true allergic reaction and side effects to a previously prescribed opioid is crucial.
 

How should extravasation 
injuries be treated?

December 07, 2011

Most extravasation injuries do not result in significant harm, but prompt recognition and early treatment are crucial.
 

Understanding the appropriate and effective use of vancomycin

November 09, 2011

Vancomycin should be dosed aggressively early on, with a loading dose given that is sufficient for rapid achievement of target concentrations.
 

Starting levothyroxine therapy; treating pernicious anemia

October 26, 2011

This month's topics are how to initiate treatment in patients with hypothyroidism and cobalamin dosing in patients with pernicious anemia.
 

Simvastatin dosing restrictions; monitoring amiodarone therapy

September 20, 2011

This month's topics are preventing myopathies when using simvastatin and safe use of amiodarone.
 

Erythromycin for GI motility; 
sunscreens; enoxaparin in obesity

August 17, 2011

This month's topics are using erythromycin for GI motility, choosing a sunscreen, and DVT prophylaxis with enoxaparin in obese patients.
 
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